The city is the favorite of bookmakers to claim the competition of elite clubs in Europe, with a price of 9/2.
That despite the fact that Guardiola’s men lost emphatically 5-1 in the aggregate against Liverpool in the quarterfinals last year.
The one-leg duel against their city rivals was played in vociferous circumstances, as the Citizens team bus was attacked by Liverpool fans before the first leg.
Fans of the city then succumbed to the Anfield cauldron and conceded three goals in the first half hour, before losing the home game 2-1.
Manchester City: Ederson, Daniel Grimshaw; Kyle Walker, Danilo, Vincent Kompany, John Stones, Aymeric Laporte, Eliaquim Mangala, Benjamin Mendy, Nicolas Otamendi; Raheem Sterling, Ilkay Gundogan, Kevin De Bruyne, Fabian Delph, Leroy Sane, Bernardo Silva, David Silva, Fernandinho, Riyad Mahrez, Olexandr Zinchenko; Sergio Aguero, Gabriel Jesus
Shakhtar Donetsk: Oleksii Shevchenko, Andriy Pyatov, Oleh Kudryk; Bohdan Butko, Serhiy Kryvtsov, David Khocholava, Ivan Ordets, Mykola Matviyenko, Ismaily, Yaroslav Rakitskiy; Taras Stepanenko, Taison, Bruno Bentinho, Marlos, Alan Patrick, Wellington Nem, Maycon de Andrade Barberán, Cipriano Marcos Robson, Andriy Totovytskiy, Serhiy Bolbat, Viktor Kovalenko, Oleg Danchenko, Fernando Dos Santos Pedro; Olarenwaju Kayode, Junior Moraes
Lyon: Anthony Lopes, Anthony Racioppi, Mathieu Gorgelin, Dorian Grange; Mapou Yanga-Mbiwa, Rafael, Jason Denayer, Marcelo, Leo Dubois, Jeremy Morel, Fernando Marcal, Ferland Mendy, Kenny Tete, Oumar Solet; Martin Terrier, Houssem Aouar, Jordan Ferri, Pape Cheikh, Tanguy Ndombele, Ousseynou Ndiyae; Moussa Dembele, Memphis Depay, Nabil Fekir, Maxwel Cornet
Hoffenheim: Oliver Baumann, Gregor Kobel; Joshua Brenet, Pavel Kaderabek, Ermin Bicakcic, Kassim Adams Nuhu, Nico Schulz, Benjamin Hubner, Justin Hoogma, Kevin Akpoguma, Stefan Posch; Havard Nordtveit, Dennis Geiger, Kerem Demirbay, Florian Grillitsch, Leonardo Bittencourt, Steven Zuber, Noam Amiri, Kevin Vogt, Vincenzo Grifo; Reiss Nelson, Ishak Belfodil, Andrej Kramaric, Adam Szalai, Joelinton
Group F of the Champions League consists of teams from England, Germany, France and Ukraine.
Pep Guardiola’s Manchester City will have to find a way beyond Hoffenheim, Lyon and, for the second consecutive season, Shakhtar Donetsk if they are going to fight for the trophy.
For its part, the Bundesliga Hoffenheim hopes to impress by competing in the group stage for the first time in club history.